Trinov Capelli Fidia (già PGE1, dr. Brotzu)
- Thread starter stefinaste
- Start date
Interessante, pero il fatto che restera un cosmetico potra influire sul prezzo, e probabilmente sara prodotto da una sola casa?
E finalmente qualcosa che non riguarda direttamente l'eliminazione del dht, perche io ad esempio la fina non la uso piu, in quanto non funzionava, e utilizzo solo il minoxidil per il mantenimento.
E finalmente qualcosa che non riguarda direttamente l'eliminazione del dht, perche io ad esempio la fina non la uso piu, in quanto non funzionava, e utilizzo solo il minoxidil per il mantenimento.
Forse anche l'utilizzo dell'equolo come anti dht, è in parte una risposta, va bene anche per l'androgenetica, oltre al fatto che è stato detto dal prof. visto che queste patologie hanno in comune il problema al microcircolo e la lozione incide su questo, come già è stato detto.
Leggete qui molto interessante http://www.sumobrain.com/patents/wipo/Liposomes-containing-di-homo-gamma/WO2015170247A1.html
Ottimo Mika.
Le conclusioni dello studio evidenziano un risultato inatteso migliore, a concentrazioni inferiori di sostanze attive (DGLA).
Gli effetti straordinari che vengono riscontrati dalle composizioni della presente invenzione sono quindi dovuti a sinergie tra singoli componenti, promosse dalle caratteristiche dei liposomi utilizzati (l'utilizzo del solo DGLA, invece, non ha dato alcun risultato):
From the observations reported here, first of all, it can be inferred that the formulations object of the present invention are clinically efficient in:
· stopping hair loss; • promoting hair regrowth in areas with alopecia;
• strengthening and fortifying hair, bringing it back to its original state
both in male and female subjects with forms of hair reduction or actual alopecia due to different causes, and in menopausal women.
Formulations set up here additionally:
• do not contain potentially toxic substances or that may interfere with other active ingredients;
· are not irritating for the skin: even after long term application no evidence of irritation or inflammation was reported;
• are stable in time: analysis carried out on the content of the vials 30 days after preparation detects
· significant Ñæ values in terms of stability, particularly for formulations containing 2% or, better, 3% stearylamine
• an unchanged content of active substances enclosed in liposomes;
· can be stored at room temperature and in a ready-to- use form;
and, surprisingly
• act more quickly and more effectively: comparison tests clearly demonstrate that group 1 has a more rapid, more substantial improvement and, mainly, it involves all the patients as compared with group 2, treated with Lotion B.
Again, it should be recalled that Lotion B contains PGE1 and equol in 1:1 ratio, while Lotion A contains 30% less of active substance (DGLA) . This means that the findings of the present invention exert an unexpectedly superior effect than what known, at markedly lower concentrations of active substances.
Le conclusioni dello studio evidenziano un risultato inatteso migliore, a concentrazioni inferiori di sostanze attive (DGLA).
Gli effetti straordinari che vengono riscontrati dalle composizioni della presente invenzione sono quindi dovuti a sinergie tra singoli componenti, promosse dalle caratteristiche dei liposomi utilizzati (l'utilizzo del solo DGLA, invece, non ha dato alcun risultato):
From the observations reported here, first of all, it can be inferred that the formulations object of the present invention are clinically efficient in:
· stopping hair loss; • promoting hair regrowth in areas with alopecia;
• strengthening and fortifying hair, bringing it back to its original state
both in male and female subjects with forms of hair reduction or actual alopecia due to different causes, and in menopausal women.
Formulations set up here additionally:
• do not contain potentially toxic substances or that may interfere with other active ingredients;
· are not irritating for the skin: even after long term application no evidence of irritation or inflammation was reported;
• are stable in time: analysis carried out on the content of the vials 30 days after preparation detects
· significant Ñæ values in terms of stability, particularly for formulations containing 2% or, better, 3% stearylamine
• an unchanged content of active substances enclosed in liposomes;
· can be stored at room temperature and in a ready-to- use form;
and, surprisingly
• act more quickly and more effectively: comparison tests clearly demonstrate that group 1 has a more rapid, more substantial improvement and, mainly, it involves all the patients as compared with group 2, treated with Lotion B.
Again, it should be recalled that Lotion B contains PGE1 and equol in 1:1 ratio, while Lotion A contains 30% less of active substance (DGLA) . This means that the findings of the present invention exert an unexpectedly superior effect than what known, at markedly lower concentrations of active substances.
Scusate l'ignoranza ma questa è una relazione sul prodotto?
Ragà me la sono letta tutta,sembrano facciano davvero sul serio.
Voglio restare coi piedi per terra però i risultati sono davvero entusiasmanti a detta di questo documento.
Riporto anche questo stralcio:
Treatments :
Lotion A, prepared according to the present example 4 ; Lotion B, comparison, prepared as described in WO 2011/095938 (example 1) and then containing PGE1 and S- equol in 1:1 ratio
Lotion C, containing 7 mg of PGE1 enclosed in liposomes as the only active substance, prepared according to method A;
Lotion D, containing 1,25 mg of DGLA enclosed in liposomes as the only active substance, prepared according to method A.
Groups of patients:
• Group 1: 10 (6 male, 4 female) patients treated for 120 days with 1 ml/day of Lotion A to be applied on a well defined area of the scalp;
• Group 2: 10 (5 male, 5 female) patients treated for 120 days with 1 ml/day of Lotion B to be applied on a well defined area of the scalp;
• Group 3: 6 female menopausal patients for about 3 years, without specific diseases related to hair reduction, treated for 120 days with 1 ml/day of Lotion A to be applied on a well defined area of the scalp.
• Group 4: 4 (2 male, 2 female) patients treated for 120 days with 1 ml/day of Lotion C to be applied on a well defined area of the scalp; • Group 5: 4 (2 male, 2 female) patients treated for 120 days with 1 ml/day of Lotion D to be applied on a well defined area of the scalp;
Evaluation was carried out at pre-determined time points by dermoscopy and direct observation with photographic detections.
Results
On day 7 : both group 1 and group 2 experience a reduction of hair loss, defined substantial by patients of group 1 and modest by those of group 2. Group 3 feels hair as more robust. Groups 4 and 5 do not report any variation;
On day 20: in group 1 all the patients have stopped losing hair and report the presence of a substantial fuzz. In group 2 hair loss has stopped in 6 patients and fuzz, where present, is more modest (in terms of number/cm 2 ) . Group 3 reports an aesthetic improvement related to hair brightness. Group 4 reports a minimal reduction in hair loss. Group 5 does not report any variation;
On day 45: in group 1, fuzz has grown markedly stronger and takes the colour and consistency of natural hair. In group 2, as expected, all the patients have stopped losing hair, but only some of them report a certain degree of regrowth, fuzz is very weak and not completely coloured yet. Group 3 reports disappearance of split ends. Group 4 reports arrested hair loss in all the subjects and, in some of them, presence of weak fuzz. Group 5 does not report any variation;
On day 90: in group 1 all the patients report total disappearance of hair reduction areas that have been replaced by robust and shiny hair. In group 2 hair reduction is still visible, even if areas are all covered with thick fuzz. Group 3 confirms a general hair improvement. Groups 4 and 5 do not record variations from the previous evaluation;
On day 120: group 1 confirms results already seen at day 90. Group 2 continues improvement, even if in some patients of male gender the fuzz has not got the characteristics of strength and colour typical of hair yet. Group 3 confirms results previously obtained. Groups 4 and 5 do not record variations from the previous evaluation .
During the whole phase of the study the patients' skin was regularly assayed by dermoscopy, highlighting an improvement of circulation. Additionally, treated skin did not display allergic or inflammatory reactions.
Ragà me la sono letta tutta,sembrano facciano davvero sul serio.
Voglio restare coi piedi per terra però i risultati sono davvero entusiasmanti a detta di questo documento.
Riporto anche questo stralcio:
Treatments :
Lotion A, prepared according to the present example 4 ; Lotion B, comparison, prepared as described in WO 2011/095938 (example 1) and then containing PGE1 and S- equol in 1:1 ratio
Lotion C, containing 7 mg of PGE1 enclosed in liposomes as the only active substance, prepared according to method A;
Lotion D, containing 1,25 mg of DGLA enclosed in liposomes as the only active substance, prepared according to method A.
Groups of patients:
• Group 1: 10 (6 male, 4 female) patients treated for 120 days with 1 ml/day of Lotion A to be applied on a well defined area of the scalp;
• Group 2: 10 (5 male, 5 female) patients treated for 120 days with 1 ml/day of Lotion B to be applied on a well defined area of the scalp;
• Group 3: 6 female menopausal patients for about 3 years, without specific diseases related to hair reduction, treated for 120 days with 1 ml/day of Lotion A to be applied on a well defined area of the scalp.
• Group 4: 4 (2 male, 2 female) patients treated for 120 days with 1 ml/day of Lotion C to be applied on a well defined area of the scalp; • Group 5: 4 (2 male, 2 female) patients treated for 120 days with 1 ml/day of Lotion D to be applied on a well defined area of the scalp;
Evaluation was carried out at pre-determined time points by dermoscopy and direct observation with photographic detections.
Results
On day 7 : both group 1 and group 2 experience a reduction of hair loss, defined substantial by patients of group 1 and modest by those of group 2. Group 3 feels hair as more robust. Groups 4 and 5 do not report any variation;
On day 20: in group 1 all the patients have stopped losing hair and report the presence of a substantial fuzz. In group 2 hair loss has stopped in 6 patients and fuzz, where present, is more modest (in terms of number/cm 2 ) . Group 3 reports an aesthetic improvement related to hair brightness. Group 4 reports a minimal reduction in hair loss. Group 5 does not report any variation;
On day 45: in group 1, fuzz has grown markedly stronger and takes the colour and consistency of natural hair. In group 2, as expected, all the patients have stopped losing hair, but only some of them report a certain degree of regrowth, fuzz is very weak and not completely coloured yet. Group 3 reports disappearance of split ends. Group 4 reports arrested hair loss in all the subjects and, in some of them, presence of weak fuzz. Group 5 does not report any variation;
On day 90: in group 1 all the patients report total disappearance of hair reduction areas that have been replaced by robust and shiny hair. In group 2 hair reduction is still visible, even if areas are all covered with thick fuzz. Group 3 confirms a general hair improvement. Groups 4 and 5 do not record variations from the previous evaluation;
On day 120: group 1 confirms results already seen at day 90. Group 2 continues improvement, even if in some patients of male gender the fuzz has not got the characteristics of strength and colour typical of hair yet. Group 3 confirms results previously obtained. Groups 4 and 5 do not record variations from the previous evaluation .
During the whole phase of the study the patients' skin was regularly assayed by dermoscopy, highlighting an improvement of circulation. Additionally, treated skin did not display allergic or inflammatory reactions.
I tempi mi sembrano proprio eccessivi, già il fatto che in una settimana ci sia una riduzione pesante della caduta mi sembra qualcosa di eccessivo , poi 45 gg per avere ricrescita...
Io ci spero con tutto me stesso peró questi dati mi puzzano [
]
Tra l'altro sarei disposto a spendere davvero tanto per una lozione del genere...
Io ci spero con tutto me stesso peró questi dati mi puzzano [
]Tra l'altro sarei disposto a spendere davvero tanto per una lozione del genere...
A me 45 giorni per vedere qualcosa di nuovo che spunta non mi pare un tempo così eccessivo, una settimana per riduzione pesante della caduta invece sì, anche se di per sé riduzione della caduta vuol dire poco visto che ci sono molti fattori in gioco come ad esempio la stagionalità.
strengthening and fortifying hair, bringing it back to its original state both in male and female subjects with forms of hair reduction or actual alopecia due to different causes
Effettivamente potevano specificare meglio dicendo da quale tipo di alopecia erano affetti i tester dei vari gruppi
Effettivamente potevano specificare meglio dicendo da quale tipo di alopecia erano affetti i tester dei vari gruppi
Sembra quasi che tutti i tipi di alopecia, alla fine, inducano la caduta del capello per via del ridotto apporto di sangue.
Se fosse così, indipendentemente che ci sia di mezzo il DHT o il sistema immunitario o altro, questo farmaco dovrebbe funzionare su tutte le perdite di capelli.
O almeno è quello che si intuisce dall'articolo...
Se fosse così, indipendentemente che ci sia di mezzo il DHT o il sistema immunitario o altro, questo farmaco dovrebbe funzionare su tutte le perdite di capelli.
O almeno è quello che si intuisce dall'articolo...
salvatore81 ha scritto:
Forse anche l'utilizzo dell'equolo come anti dht, è in parte una risposta, va bene anche per l'androgenetica, oltre al fatto che è stato detto dal prof. visto che queste patologie hanno in comune il problema al microcircolo e la lozione incide su questo, come già è stato detto.
Come ha scritto Salvatore: se utilizzano un anti dht credo che una connessione con l'androgenetica ci sia. Poi non so quanto il dht influenzi l'areata, ne so davvero poco.
Forse anche l'utilizzo dell'equolo come anti dht, è in parte una risposta, va bene anche per l'androgenetica, oltre al fatto che è stato detto dal prof. visto che queste patologie hanno in comune il problema al microcircolo e la lozione incide su questo, come già è stato detto.
Come ha scritto Salvatore: se utilizzano un anti dht credo che una connessione con l'androgenetica ci sia. Poi non so quanto il dht influenzi l'areata, ne so davvero poco.